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##  196 results 

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### In Press

Hong S YKKK Joo JH. [Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz903/5588348?guestAccessKey=e2631110-c38e-4bed-9930-14db5f16751f) Nucleic Acids Research. 2019:doi: 10.1093/nar/gkz903.



 

 

Hong S YKKK Joo JH. [Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz903/5588348?guestAccessKey=e2631110-c38e-4bed-9930-14db5f16751f) Nucleic Acids Research. 2019:doi: 10.1093/nar/gkz903.



 

 

 

- [ picture\_as\_pdfHong et al. 2019](/sites/g/files/omnuum7236/files/kleckner_lab/files/gkz903.pdf)
 
- [ picture\_as\_pdfHong et al. 2019](/sites/g/files/omnuum7236/files/kleckner_lab/files/gkz903.pdf)
 
 

 



### 2019

Wang S, Liu Y, Shang Y, Zhai B, Yang X, Kleckner N, Zhang L. [Crossover Interference, Crossover Maturation, and Human Aneuploidy](/publications/crossover-interference-crossover-maturation-and-human-aneuploidy). Bioessays. 2019;41(10):e1800221. doi:10.1002/bies.201800221



 

 

Wang S, Liu Y, Shang Y, Zhai B, Yang X, Kleckner N, Zhang L. [Crossover Interference, Crossover Maturation, and Human Aneuploidy](/publications/crossover-interference-crossover-maturation-and-human-aneuploidy). Bioessays. 2019;41(10):e1800221. doi:10.1002/bies.201800221



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 A striking feature of human female sexual reproduction is the high level of gametes that exhibit an aberrant number of chromosomes (aneuploidy). A high baseline observed in women of prime reproductive age is followed by a dramatic increase in older women... 

 

 

 

Dubois E, De Muyt A, Soyer J, Budin K, Legras M, Piolot T, Debuchy R, Kleckner N, Zickler D, Espagne E. [Building bridges to move recombination complexes](/publications/building-bridges-move-recombination-complexes). Proc Natl Acad Sci U S A. 2019;116(25):12400–12409. doi:10.1073/pnas.1901237116



 

 

Dubois E, De Muyt A, Soyer J, Budin K, Legras M, Piolot T, Debuchy R, Kleckner N, Zickler D, Espagne E. [Building bridges to move recombination complexes](/publications/building-bridges-move-recombination-complexes). Proc Natl Acad Sci U S A. 2019;116(25):12400–12409. doi:10.1073/pnas.1901237116



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 A central feature of meiosis is pairing of homologous chromosomes, which occurs in two stages: coalignment of axes followed by installation of the synaptonemal complex (SC). Concomitantly, recombination complexes reposition from on-axis association to the... 

 

 

 

Wang S, Veller C, Sun F, Ruiz-Herrera A, Shang Y, Liu H, Zickler D, Chen Z, Kleckner N, Zhang L. [Per-Nucleus Crossover Covariation and Implications for Evolution](/publications/nucleus-crossover-covariation-and-implications-evolution). Cell. 2019;177(2):326–338.e16. doi:10.1016/j.cell.2019.02.021



 

 

Wang S, Veller C, Sun F, Ruiz-Herrera A, Shang Y, Liu H, Zickler D, Chen Z, Kleckner N, Zhang L. [Per-Nucleus Crossover Covariation and Implications for Evolution](/publications/nucleus-crossover-covariation-and-implications-evolution). Cell. 2019;177(2):326–338.e16. doi:10.1016/j.cell.2019.02.021



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Crossing over is a nearly universal feature of sexual reproduction. Here, analysis of crossover numbers on a per-chromosome and per-nucleus basis reveals a fundamental, evolutionarily conserved feature of meiosis: within individual nuclei, crossover... 

 

 

 

Veller C, Kleckner N, Nowak M. [A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel’s second law](/publications/rigorous-measure-genome-wide-genetic-shuffling-takes-account-crossover). Proc Natl Acad Sci U S A. 2019;116(5):1659–1668. doi:10.1073/pnas.1817482116



 

 

Veller C, Kleckner N, Nowak M. [A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel’s second law](/publications/rigorous-measure-genome-wide-genetic-shuffling-takes-account-crossover). Proc Natl Acad Sci U S A. 2019;116(5):1659–1668. doi:10.1073/pnas.1817482116



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Comparative studies in evolutionary genetics rely critically on evaluation of the total amount of genetic shuffling that occurs during gamete production. Such studies have been hampered by the absence of a direct measure of this quantity. Existing... 

 

 

 

 



### 2018

Kleckner N, Chatzi K, White M, Fisher J, Stouf M. [Coordination of Growth, Chromosome Replication/Segregation, and Cell Division in ](/publications/coordination-growth-chromosome-replicationsegregation-and-cell-division). Front Microbiol. 2018;9:1469. doi:10.3389/fmicb.2018.01469



 

 

Kleckner N, Chatzi K, White M, Fisher J, Stouf M. [Coordination of Growth, Chromosome Replication/Segregation, and Cell Division in ](/publications/coordination-growth-chromosome-replicationsegregation-and-cell-division). Front Microbiol. 2018;9:1469. doi:10.3389/fmicb.2018.01469



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Bacterial cells growing in steady state maintain a 1:1:1 relationship between an appropriate mass increase, a round of DNA replication plus sister chromosome segregation, and cell division. This is accomplished without the cell cycle engine found in... 

 

 

 

 



### 2017

Tessé S, Bourbon H-M, Debuchy R, Budin K, Dubois E, Liangran Z, Antoine R, Piolot T, Kleckner N, Zickler D, et al. [Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction](/publications/asy2mer2-evolutionarily-conserved-mediator-meiotic-recombination-pairing). Genes Dev. 2017;31(18):1880–1893. doi:10.1101/gad.304543.117



 

 

Tessé S, Bourbon H-M, Debuchy R, Budin K, Dubois E, Liangran Z, Antoine R, Piolot T, Kleckner N, Zickler D, et al. [Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction](/publications/asy2mer2-evolutionarily-conserved-mediator-meiotic-recombination-pairing). Genes Dev. 2017;31(18):1880–1893. doi:10.1101/gad.304543.117



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Meiosis is the cellular program by which a diploid cell gives rise to haploid gametes for sexual reproduction. Meiotic progression depends on tight physical and functional coupling of recombination steps at the DNA level with specific organizational... 

 

 

 

Gladyshev E, Kleckner N. [DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora](/publications/dna-sequence-homology-induces-cytosine-thymine-mutation-heterochromatin). Nat Genet. 2017;49(6):887–894. doi:10.1038/ng.3857



 

 

Gladyshev E, Kleckner N. [DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora](/publications/dna-sequence-homology-induces-cytosine-thymine-mutation-heterochromatin). Nat Genet. 2017;49(6):887–894. doi:10.1038/ng.3857



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Most eukaryotic genomes contain substantial amounts of repetitive DNA organized in the form of constitutive heterochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and C5 cytosine methylation (5mC). In the fungus... 

 

 

 

Wang S, Kleckner N, Zhang L. [Crossover maturation inefficiency and aneuploidy in human female meiosis](/publications/crossover-maturation-inefficiency-and-aneuploidy-human-female-meiosis). Cell Cycle. 2017;16(11):1017–1019. doi:10.1080/15384101.2017.1319689



 

 

Wang S, Kleckner N, Zhang L. [Crossover maturation inefficiency and aneuploidy in human female meiosis](/publications/crossover-maturation-inefficiency-and-aneuploidy-human-female-meiosis). Cell Cycle. 2017;16(11):1017–1019. doi:10.1080/15384101.2017.1319689



 

 

 

 

Gladyshev E, Kleckner N. [Recombination-independent recognition of DNA homology for repeat-induced point mutation](/publications/recombination-independent-recognition-dna-homology-repeat-induced-point-0). Curr Genet. 2017;63(3):389–400. doi:10.1007/s00294-016-0649-4



 

 

Gladyshev E, Kleckner N. [Recombination-independent recognition of DNA homology for repeat-induced point mutation](/publications/recombination-independent-recognition-dna-homology-repeat-induced-point-0). Curr Genet. 2017;63(3):389–400. doi:10.1007/s00294-016-0649-4



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Numerous cytogenetic observations have shown that homologous chromosomes (or individual chromosomal loci) can engage in specific pairing interactions in the apparent absence of DNA breakage and recombination, suggesting that canonical recombination... 

 

 

 

Wang S, Hassold T, Hunt P, White M, Zickler D, Kleckner N, Zhang L. [Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis](/publications/inefficient-crossover-maturation-underlies-elevated-aneuploidy-human). Cell. 2017;168(6):977–989.e17. doi:10.1016/j.cell.2017.02.002



 

 

Wang S, Hassold T, Hunt P, White M, Zickler D, Kleckner N, Zhang L. [Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis](/publications/inefficient-crossover-maturation-underlies-elevated-aneuploidy-human). Cell. 2017;168(6):977–989.e17. doi:10.1016/j.cell.2017.02.002



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Meiosis is the cellular program that underlies gamete formation. For this program, crossovers between homologous chromosomes play an essential mechanical role to ensure regular segregation. We present a detailed study of crossover formation in human male... 

 

 

 

Liu C, Danilowicz C, Kleckner N, Prentiss M. [Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA](/publications/single-molecule-identification-homology-dependent-interactions-between). Nucleic Acids Res. 2017;45(2):894–901. doi:10.1093/nar/gkw758



 

 

Liu C, Danilowicz C, Kleckner N, Prentiss M. [Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA](/publications/single-molecule-identification-homology-dependent-interactions-between). Nucleic Acids Res. 2017;45(2):894–901. doi:10.1093/nar/gkw758



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
 Long non-coding RNAs (lncRNAs) are prominently associated with chromosomes in an ever-increasing diversity of roles. To provide further insight into the potential nature of these associations, we have explored, for the first time, the interaction of long... 

 

 

 

 



 

 

 

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