A mechanical basis for chromosome function.
Publication information:
Kleckner N, Zickler D, Jones G, Dekker J, Padmore R, Henle J, Hutchinson J. A mechanical basis for chromosome function. Proc Natl Acad Sci U S A. 2004;101(34):12592–7. doi:10.1073/pnas.0402724101
Abstract
We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.